effect of d-003, a mixture of high molecular weight aliphatic acids, on glucocorticoid- and lipopolysaccharides (lps)-induced osteonecrosis
نویسندگان
چکیده
osteonecrosis (on) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. corticoid-induced on in rats and lipopolysaccharide (lps)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. d-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the osteoclast apoptosis. this study investigated the effects of d-003 on corticoid- and lps-induced on in rats and rabbits. corticoid-induced on :rats were randomized into five groups. a negative control and four groups treated with prednisolone 6 mg/kg: a positive control and three treated with d-003 (5, 25 and 200 mg/kg) for 80 days. all positive controls presented on areas. d-003 significantly reduced the numbers and proportions of on lesions, as compared to the positive control group. lps-induced on in rabbits :rabbits were randomized into five groups: a negative control and four injected with a single intra-venous injection of lps (10 µg/kg) including a positive control and three with d-003 (5, 25 and 200 mg/kg) for 30 days. on was seen in all positive controls. the incidence of on and the number of on lesions in the groups treated with d-003 (25 and 200 mg/kg) was significantly lower compared to the positive controls. lps injection significantly increased the size of bone marrow fat cells in positive controls and such increase was significantly decreased by d-003. in conclusion, d-003 reduced on lesions in corticoid- and lps-induced on and also the size of bone marrow fat cells in rabbits with lps.
منابع مشابه
Effect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis
Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...
متن کاملEffect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis
Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...
متن کاملEffect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis
Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...
متن کاملEffects of D-003 on Lipopolysaccharides-induced Osteonecrosis in Rabbits
D-003, a mixture of high molecular weight acids, inhibits cholesterol synthesis prior to mevalonate and prevents osteoporosis induced by ovariectomy in rats, and both osteoporosis and osteonecrosis induced by corticoids in rats. The aim of this study was to investigate effects of D-003 on lipopolysaccharides-induced osteonecrosis in rabbits. Animals were randomized into 5 groups: a sham and fou...
متن کاملEffect of D-003, a mixture of very high molecular weight aliphatic acids purified from sugarcane wax, on serum lipid peroxidation (LP) markers in elderly
Background: D-003 is a mixture of long-chain aliphatic primary acids purified from sugar cane wax with cholesterol-lowering and preventive effects on lipoprotein lipid peroxidation (LP) proven in experimental and clinical studies. Objectives: To investigate if D-003 favourably modifies LP markers on older individuals. Methods: This double-blinded, randomized, placebo-controlled study investigat...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۴، صفحات ۱۲۰۱-۱۲۰۸
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